Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

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Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

Epithelial-mesenchymal transition (EMT) is required for mesodermal differentiation during development. The zinc-finger transcription factor, Snail1, can trigger EMT and is sufficient to transcriptionally reprogram epithelial cells toward a mesenchymal phenotype during neoplasia and fibrosis. Whether Snail1 also regulates the behavior of terminally differentiated mesenchymal cells remains unexpl...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2009

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.200810113